Osmolyte Induced Tumorigenesis and Metastasis: Interactions With Intrinsically Disordered Proteins
نویسندگان
چکیده
منابع مشابه
Evolution of Interactions Involving Intrinsically Disordered Proteins
Åberg, E. 2018. Evolution of Interactions Involving Intrinsically Disordered Proteins. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1424. 44 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0226-3. This thesis describes the evolution of intrinsically disordered proteins and their interaction partners. The work presented is a combination of ph...
متن کاملIntrinsically disordered proteins.
Our understanding of protein function has been predominated by the view that proteins need to adopt a defined three dimensional structure to be able to carry out their function. Indeed, crystal structures of numerous proteins have been instrumental in establishing the structure– function paradigm. For example, the structures of numerous enzymes have highlighted the need for particular chemical ...
متن کاملIntrinsically Disordered Proteins
In the same way that neither a messy lab bench nor a clean one is a reliable indicator of a researcher’s productivity, a protein’s function cannot be judged solely on the basis of its neatly folded and stable domains. As evidenced by recent work discussed in this Select, we are learning that intrinsically disordered regions feature in many of the cell’s most productive multitaskers, proteins wh...
متن کاملOsmolyte-Induced Folding and Stability of Proteins: Concepts and Characterization
It is well-known that the typical protein’s three-dimensional structure is relatively unstable in harsh conditions. A practical approach to maintain the folded state and thus improve the stability and activity of proteins in unusual circumstances is to directly apply stabilizing substances such as osmolytes to the protein-containing solutions. Osmolytes as natural occurring organic molecules ty...
متن کاملModeling Intrinsically Disordered Proteins with Bayesian Statistics
The characterization of intrinsically disordered proteins is challenging because accurate models of these systems require a description of both their thermally accessible conformers and the associated relative stabilities or weights. These structures and weights are typically chosen such that calculated ensemble averages agree with some set of prespecified experimental measurements; however, th...
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ژورنال
عنوان ژورنال: Frontiers in Oncology
سال: 2018
ISSN: 2234-943X
DOI: 10.3389/fonc.2018.00353